A meta-analysis has evaluated the efficacy and safety of Ustekinumab ( Stelara ) in the therapy of plaque psoriasis.
The efficacy was estimated using relative risk of Psoriasis Area and Severity Index ( PASI ) 75 response rate at the week 12 endpoint in clinical trials, and adverse effects were also analyzed.
Six randomized control trials consistent with the inclusion criteria were selected and reviewed.
Ustekinumab 45 mg group and 90 mg group could get better therapeutic effect compared with the placebo group ( all P less than 0.00001 ).
Furthermore, Ustekinumab 90 mg group was more effective than Ustekinumab 45 mg group ( P=0.01 ).
Adverse effects in the 6 trials were mentioned including headache, upper respiratory tract infection, nasopharyngtis, infection, serious infection, cardiovascular events, and malignant tumors.
There were no statistically significant differences of these adverse effects among three groups ( all P greater than 0.05 ), except that infection rate in Ustekinumab 45 mg group was higher than the placebo group ( P=0.02 ).
In conclusion, Ustekinumab is an effective and safe therapeutic method for plaque psoriasis. However, further longer time analysis of safety is needed. ( Xagena )
Liu Y et al, Chin Med Sci J 2014;29:131-138