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Left ventricular dyssynchrony in patients with psoriasis is an early manifestation of heart involvement


Psoriasis is an inflammatory disorder, which has been reported to be associated with cardiovascular risks. Although increased cardiovascular risks in psoriasis are well established, there are no data about changes of contraction synchrony in psoriasis.
Therefore, researchers have studied the left ventricular ( LV ) contraction synchrony in patients with psoriasis with narrow QRS and normal ejection fraction.

Fifty patients with psoriasis and 50 age- and sex-matched control subjects were included in the study. LV dyssynchrony was investigated by color-coded tissue Doppler imaging.

In the psoriasis group, the mean high-sensitive C-reactive protein values were significantly higher compared with the controls.

Peak A velocity, deceleration time, isovolumetric relaxation time, and E/E' values were higher in the psoriasis group; however, E/A ratio and average Em were higher in the control group.

LV systolic dyssynchrony parameters [ including standard deviation of Ts of the 12 LV segments ( Ts-SD-12 ), maximal difference in Ts between any two of the 12 LV segments, standard deviation of Ts of the six basal LV segments, and maximal difference in Ts between any two of the six basal LV segments ] were found to be higher in the psoriasis group.

The patients with ventricular dyssynchrony ( a Ts-SD-12 greater than 34.4 ms ) were higher in the psoriasis group than the control group ( 34% vs 6%, P less than 0.01 ).

In patients with psoriasis with normal ejection fractions and narrow QRS, left ventricular systolic dyssynchrony is an early manifestation of heart involvement and may coexist with diastolic dysfunction. ( Xagena )

Bulbul Sen B et al, Int J Dermatol 2014;53:1221-1227

XagenaMedicine_2014



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